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doi:10.1016/j.msec.2018.02.010 51

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Cultured mouse zygotes were treated with H 2 O 2 in dose response studies ( 2 O 2 -treated zygotes had elevated levels of ROS, as well as increased oxidative damage, activation of the G2/M checkpoint, decreased cleavage and blastocyst rates, and increased rates of apoptosis